Does Ezetimibe Interact With Fenofibrate?
When used in combination with a statin, fenofibrate, or other LDL-C lowering therapy, ezetimibe tablets are contraindicated in patients for whom a statin, fenofibrate, or other LDL-C lowering therapy are contraindicated.
Severity: Contraindicated
Severity basis: contraindications section (keywords: contraindicated). Combining Ezetimibe (Cholesterol absorption inhibitor) and Fenofibrate (Fibrate) is classified as a contraindicated interaction.
What to Do
This combination is contraindicated on the FDA label. Do not take these together unless your prescriber explicitly directs it.
From the FDA Label
When used in combination with a statin, fenofibrate, or other LDL-C lowering therapy, ezetimibe tablets are contraindicated in patients for whom a statin, fenofibrate, or other LDL-C lowering therapy are contraindicated.
Source: FDA structured product labeling (set_id 02b00cb2-7253-4fb4-a216-53691a929a28).
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.