Does Ezetimibe Interact With Simvastatin?
In a clinical study (median follow-up 3.9 years) of patients at high risk of CVD and with well-controlled LDL-C levels on simvastatin 40 mg/day with or without ezetimibe 10 mg/day, there was no incremental benefit on cardiovascular outcomes with the addition of lipid-modifying doses of niacin.
Severity: Minor
Severity basis: drug interactions section. Combining Ezetimibe (Cholesterol absorption inhibitor) and Simvastatin (HMG-CoA reductase inhibitor (statin)) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
In a clinical study (median follow-up 3.9 years) of patients at high risk of CVD and with well-controlled LDL-C levels on simvastatin 40 mg/day with or without ezetimibe 10 mg/day, there was no incremental benefit on cardiovascular outcomes with the addition of lipid-modifying doses of niacin.
Source: FDA structured product labeling (set_id 00896fff-081d-4553-be8c-1999a8a73dda).
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Ezetimibe Interactions
Other Simvastatin Interactions
- Simvastatin + Clarithromycin(contraindicated)
- Simvastatin + Cyclosporine(contraindicated)
- Simvastatin + Gemfibrozil(contraindicated)
- Simvastatin + Itraconazole(contraindicated)
- Simvastatin + Colchicine(moderate)
- Simvastatin + Digoxin(moderate)
- Simvastatin + Phenytoin(moderate)
- Simvastatin + Ticagrelor(moderate)
- Simvastatin + Amiodarone(minor)
- Simvastatin + Amlodipine(minor)
- Simvastatin + Dapagliflozin(minor)
- Simvastatin + Diltiazem(minor)
- Simvastatin + Fluconazole(minor)
- Simvastatin + Ketoconazole(minor)
- Simvastatin + Ramipril(minor)
- Simvastatin + Rifampin(minor)
- Simvastatin + Verapamil(minor)
- Simvastatin + Warfarin(minor)