Does Fenofibrate Interact With Gemfibrozil?

Risks are increased during co-administration with a statin (with a significantly higher rate observed for gemfibrozil), particularly in elderly patients and patients with diabetes, renal failure, or hypothyroidism ( 5.3 ).

Severity: Minor

Severity basis: warnings section. Combining Fenofibrate (Fibrate) and Gemfibrozil (Fibrate) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Risks are increased during co-administration with a statin (with a significantly higher rate observed for gemfibrozil), particularly in elderly patients and patients with diabetes, renal failure, or hypothyroidism ( 5.3 ).

Source: FDA structured product labeling (set_id 00c2f942-e839-46fc-948a-f8e2fa79ccd1).

Fenofibrate

Fibrate

Brands: Tricor, Fenoglide

View Fenofibrate safety profile

Gemfibrozil

Fibrate

Brands: Lopid

View Gemfibrozil safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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