Does Cyclosporine Interact With Fenofibrate?

7.2 Immunosuppressants Immunosuppressants such as cyclosporine and tacrolimus can produce nephrotoxicity with decreases in creatinine clearance and rises in serum creatinine, and because renal excretion is the primary elimination route of fibrate drugs including fenofibrate, there is a risk that an interaction will lead to deterioration of renal function.

Severity: Minor

Severity basis: drug interactions section. Combining Cyclosporine (Calcineurin inhibitor immunosuppressant) and Fenofibrate (Fibrate) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

7.2 Immunosuppressants Immunosuppressants such as cyclosporine and tacrolimus can produce nephrotoxicity with decreases in creatinine clearance and rises in serum creatinine, and because renal excretion is the primary elimination route of fibrate drugs including fenofibrate, there is a risk that an interaction will lead to deterioration of renal function.

Source: FDA structured product labeling (set_id 00c2f942-e839-46fc-948a-f8e2fa79ccd1).

Cyclosporine

Calcineurin inhibitor immunosuppressant

Brands: Neoral, Sandimmune, Gengraf

View Cyclosporine safety profile

Fenofibrate

Fibrate

Brands: Tricor, Fenoglide

View Fenofibrate safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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