Does Sertraline Interact With Zolpidem?

Sertraline Concomitant administration of Zolpidem and sertraline increases exposure to Zolpidem [see Clinical Pharmacology ( 12.3 )].

Severity: Minor

Severity basis: drug interactions section. Combining Sertraline (SSRI antidepressant) and Zolpidem (Sedative-hypnotic (Z-drug)) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Sertraline Concomitant administration of Zolpidem and sertraline increases exposure to Zolpidem [see Clinical Pharmacology ( 12.3 )].

Source: FDA structured product labeling (set_id 021153ce-fe27-4ed1-8d88-b4157b0ed734).

Sertraline

SSRI antidepressant

Brands: Zoloft

View Sertraline safety profile

Zolpidem

Sedative-hypnotic (Z-drug)

Brands: Ambien, Edluar

View Zolpidem safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

Questions About Your Medications?

A licensed OmniRx provider can review your full medication list and help you understand what's safe for you — no office visit required.