Does Clonazepam Interact With Sertraline?
The selective serotonin reuptake inhibitors sertraline (weak CYP3A4 inducer) and fluoxetine (CYP2D6 inhibitor), and the anti-epileptic drug felbamate (CYP2C19 inhibitor and CYP3A4 inducer) do not affect the pharmacokinetics of clonazepam.
Severity: Minor
Severity basis: drug interactions section. Combining Clonazepam (Benzodiazepine) and Sertraline (SSRI antidepressant) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
The selective serotonin reuptake inhibitors sertraline (weak CYP3A4 inducer) and fluoxetine (CYP2D6 inhibitor), and the anti-epileptic drug felbamate (CYP2C19 inhibitor and CYP3A4 inducer) do not affect the pharmacokinetics of clonazepam.
Source: FDA structured product labeling (set_id 00f323c0-e007-40df-ae7f-e6b3c7ba0aa8).
Check these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Clonazepam Interactions
Other Sertraline Interactions
- Sertraline + Aripiprazole(moderate)
- Sertraline + Carbamazepine(moderate)
- Sertraline + Phenytoin(moderate)
- Sertraline + Amitriptyline(minor)
- Sertraline + Aspirin(minor)
- Sertraline + Atenolol(minor)
- Sertraline + Bupropion(minor)
- Sertraline + Buspirone(minor)
- Sertraline + Citalopram(minor)
- Sertraline + Diazepam(minor)
- Sertraline + Digoxin(minor)
- Sertraline + Fluoxetine(minor)
- Sertraline + Levothyroxine(minor)
- Sertraline + Liothyronine(minor)
- Sertraline + Lithium(minor)
- Sertraline + Paroxetine(minor)
- Sertraline + Sumatriptan(minor)
- Sertraline + Tramadol(minor)
- Sertraline + Valproic Acid(minor)
- Sertraline + Warfarin(minor)
- Sertraline + Zolpidem(minor)