Does Sertraline Interact With Tramadol?
Serotonin Syndrome: The development of a potentially life-threatening serotonin syndrome has been reported with SNRIs and SSRIs, including Sertraline hydrochloride, alone but particularly with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St.
Severity: Minor
Severity basis: warnings section. Combining Sertraline (SSRI antidepressant) and Tramadol (Opioid analgesic) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
Serotonin Syndrome: The development of a potentially life-threatening serotonin syndrome has been reported with SNRIs and SSRIs, including Sertraline hydrochloride, alone but particularly with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St.
Source: FDA structured product labeling (set_id 00179766-980b-44b0-99d3-1fee2bb27e37).
Check these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Sertraline Interactions
- Sertraline + Aripiprazole(moderate)
- Sertraline + Carbamazepine(moderate)
- Sertraline + Phenytoin(moderate)
- Sertraline + Amitriptyline(minor)
- Sertraline + Aspirin(minor)
- Sertraline + Atenolol(minor)
- Sertraline + Bupropion(minor)
- Sertraline + Buspirone(minor)
- Sertraline + Citalopram(minor)
- Sertraline + Clonazepam(minor)
- Sertraline + Diazepam(minor)
- Sertraline + Digoxin(minor)
- Sertraline + Fluoxetine(minor)
- Sertraline + Levothyroxine(minor)
- Sertraline + Liothyronine(minor)
- Sertraline + Lithium(minor)
- Sertraline + Paroxetine(minor)
- Sertraline + Sumatriptan(minor)
- Sertraline + Valproic Acid(minor)
- Sertraline + Warfarin(minor)
- Sertraline + Zolpidem(minor)
Other Tramadol Interactions
- Tramadol + Buprenorphine Naloxone(major)
- Tramadol + Carbamazepine(moderate)
- Tramadol + Fluoxetine(moderate)
- Tramadol + Ketoconazole(moderate)
- Tramadol + Ondansetron(moderate)
- Tramadol + Phenytoin(moderate)
- Tramadol + Rifampin(moderate)
- Tramadol + Alprazolam(minor)
- Tramadol + Amiodarone(minor)
- Tramadol + Amphetamine Dextroamphetamine(minor)
- Tramadol + Bupropion(minor)
- Tramadol + Citalopram(minor)
- Tramadol + Codeine(minor)
- Tramadol + Cyclobenzaprine(minor)
- Tramadol + Desvenlafaxine(minor)
- Tramadol + Digoxin(minor)
- Tramadol + Duloxetine(minor)
- Tramadol + Escitalopram(minor)
- Tramadol + Gabapentin(minor)
- Tramadol + Lisdexamfetamine(minor)
- Tramadol + Lithium(minor)
- Tramadol + Mirtazapine(minor)
- Tramadol + Morphine(minor)
- Tramadol + Naltrexone(minor)
- Tramadol + Nortriptyline(minor)
- Tramadol + Oxycodone(minor)
- Tramadol + Paroxetine(minor)
- Tramadol + Pregabalin(minor)
- Tramadol + Trazodone(minor)
- Tramadol + Venlafaxine(minor)
- Tramadol + Warfarin(minor)