Does Sertraline Interact With Valproic Acid?

The effect of Sertraline hydrochloride on valproate levels has not been evaluated in clinical trials.

Severity: Minor

Severity basis: drug interactions section. Combining Sertraline (SSRI antidepressant) and Valproic Acid (Anticonvulsant / mood stabilizer) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

The effect of Sertraline hydrochloride on valproate levels has not been evaluated in clinical trials.

Source: FDA structured product labeling (set_id 00179766-980b-44b0-99d3-1fee2bb27e37).

Sertraline

SSRI antidepressant

Brands: Zoloft

View Sertraline safety profile

Valproic Acid

Anticonvulsant / mood stabilizer

Brands: Depakote, Depakene

View Valproic Acid safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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