Does Carbamazepine Interact With Escitalopram?

Carbamazepine Clinical Impact: Combined administration of racemic citalopram (40 mg/day for 14 days) and carbamazepine (titrated to 400 mg/day for 35 days) did not significantly affect the pharmacokinetics of carbamazepine, a CYP3A4 substrate.

Severity: Minor

Severity basis: drug interactions section. Combining Carbamazepine (Anticonvulsant) and Escitalopram (SSRI antidepressant) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Carbamazepine Clinical Impact: Combined administration of racemic citalopram (40 mg/day for 14 days) and carbamazepine (titrated to 400 mg/day for 35 days) did not significantly affect the pharmacokinetics of carbamazepine, a CYP3A4 substrate.

Source: FDA structured product labeling (set_id 0458445b-e431-4c82-86b8-90373813c10a).

Carbamazepine

Anticonvulsant

Brands: Tegretol, Carbatrol

View Carbamazepine safety profile

Escitalopram

SSRI antidepressant

Brands: Lexapro

View Escitalopram safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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