Does Aspirin Interact With Escitalopram?

If serotonin syndrome occurs, consider discontinuation of escitalopram and/or concomitant serotonergic drugs [ see Warnings and Precautions(5.2) ] Drugs That Interfere With Hemostasis (NSAIDs, Aspirin, Warfarin, etc.) Clinical Impact: Concomitant use of escitalopram and an antiplatelet or anticoagulant may potentiate the risk of bleeding.

Severity: Moderate

Severity basis: drug interactions section (keywords: caution, may potentiate, consider). Combining Aspirin (Antiplatelet / NSAID) and Escitalopram (SSRI antidepressant) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

If serotonin syndrome occurs, consider discontinuation of escitalopram and/or concomitant serotonergic drugs [ see Warnings and Precautions(5.2) ] Drugs That Interfere With Hemostasis (NSAIDs, Aspirin, Warfarin, etc.) Clinical Impact: Concomitant use of escitalopram and an antiplatelet or anticoagulant may potentiate the risk of bleeding.

Source: FDA structured product labeling (set_id 0458445b-e431-4c82-86b8-90373813c10a).

Aspirin

Antiplatelet / NSAID

Brands: Bayer, Ecotrin, Bufferin

View Aspirin safety profile

Escitalopram

SSRI antidepressant

Brands: Lexapro

View Escitalopram safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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