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    HomeMedication GuideDrug InteractionsBuprenorphine Naloxone + Naltrexone
    Contraindicated interaction

    Does Buprenorphine Naloxone Interact With Naltrexone?

    Patients currently dependent on opioids, including those currently maintained on opiate agonists (e.g., methadone ) or partial agonists (e.g., buprenorphine) Patients in acute opioid withdrawal (see WARNINGS ).

    Reviewed by the OmniRx Health clinical team•Last reviewed Jul 4, 2026

    Severity: Contraindicated

    Severity basis: contraindications section (keywords: contraindications section). Combining Buprenorphine Naloxone (Opioid dependence treatment) and Naltrexone (Opioid antagonist) is classified as a contraindicated interaction.

    What to Do

    This combination is contraindicated on the FDA label. Do not take these together unless your prescriber explicitly directs it.

    How This Interaction Works

    Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Buprenorphine Naloxone is a opioid dependence treatment and Naltrexone is a opioid antagonist; together they are documented as a contraindicated interaction. How much this matters depends on your dose, your other medications, and your overall health.

    If You Take Both Medications

    If you have been prescribed both Buprenorphine Naloxone and Naltrexone, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

    From the FDA Label

    Patients currently dependent on opioids, including those currently maintained on opiate agonists (e.g., methadone ) or partial agonists (e.g., buprenorphine) Patients in acute opioid withdrawal (see WARNINGS ).

    Source: FDA structured product labeling (set_id 00c04ff4-b6f2-466c-9ab9-813a60577db0).

    Buprenorphine Naloxone

    Opioid dependence treatment

    Brands: Suboxone, Zubsolv

    View Buprenorphine Naloxone safety profile

    Naltrexone

    Opioid antagonist

    Brands: Vivitrol, Revia

    View Naltrexone safety profile

    Check these against your full medication list in our free Interaction Checker

    Frequently Asked Questions

    Can you take Buprenorphine Naloxone and Naltrexone together?

    Buprenorphine Naloxone and Naltrexone have a documented contraindicated interaction. This combination is contraindicated on the FDA label. Do not take these together unless your prescriber explicitly directs it.

    How serious is the Buprenorphine Naloxone and Naltrexone interaction?

    It is classified as a contraindicated interaction, based on the FDA label's contraindications section (keywords: contraindications section). A contraindicated pairing generally should not be used together.

    What should I do if I'm taking both Buprenorphine Naloxone and Naltrexone?

    If you have been prescribed both Buprenorphine Naloxone and Naltrexone, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

    Questions About Your Medications?

    A licensed OmniRx provider can review your full medication list and help you understand what's safe for you — no office visit required.

    Other Naltrexone Interactions

    Sources & References

    Learn more about where our data comes from and how we write and review medical content.