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    HomeMedication GuideDrug InteractionsBuprenorphine Naloxone + Naltrexone
    Contraindicated interaction

    Does Buprenorphine Naloxone Interact With Naltrexone?

    Patients currently dependent on opioids, including those currently maintained on opiate agonists (e.g., methadone ) or partial agonists (e.g., buprenorphine) Patients in acute opioid withdrawal (see WARNINGS ).

    Severity: Contraindicated

    Severity basis: contraindications section (keywords: contraindications section). Combining Buprenorphine Naloxone (Opioid dependence treatment) and Naltrexone (Opioid antagonist) is classified as a contraindicated interaction.

    What to Do

    This combination is contraindicated on the FDA label. Do not take these together unless your prescriber explicitly directs it.

    From the FDA Label

    Patients currently dependent on opioids, including those currently maintained on opiate agonists (e.g., methadone ) or partial agonists (e.g., buprenorphine) Patients in acute opioid withdrawal (see WARNINGS ).

    Source: FDA structured product labeling (set_id 00c04ff4-b6f2-466c-9ab9-813a60577db0).

    Buprenorphine Naloxone

    Opioid dependence treatment

    Brands: Suboxone, Zubsolv

    View Buprenorphine Naloxone safety profile

    Naltrexone

    Opioid antagonist

    Brands: Vivitrol, Revia

    View Naltrexone safety profile

    Check these against your full medication list in our free Interaction Checker

    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

    Questions About Your Medications?

    A licensed OmniRx provider can review your full medication list and help you understand what's safe for you — no office visit required.

    Other Naltrexone Interactions