Does Buprenorphine Naloxone Interact With Hydrocodone Acetaminophen?
Additionally, avoid the use of mixed agonist/antagonist (e.g., pentazocine, nalbuphine, and butorphanol) or partial agonist (e.g., buprenorphine) analgesics in patients who are receiving a full opioid agonist analgesic, including hydrocodone bitartrate and acetaminophen tablets.
Severity: Major
Severity basis: warnings section (keywords: avoid). Combining Buprenorphine Naloxone (Opioid dependence treatment) and Hydrocodone Acetaminophen (Opioid analgesic combination) is classified as a major interaction.
What to Do
The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Buprenorphine Naloxone is a opioid dependence treatment and Hydrocodone Acetaminophen is a opioid analgesic combination; together they are documented as a major interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Buprenorphine Naloxone and Hydrocodone Acetaminophen, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
Additionally, avoid the use of mixed agonist/antagonist (e.g., pentazocine, nalbuphine, and butorphanol) or partial agonist (e.g., buprenorphine) analgesics in patients who are receiving a full opioid agonist analgesic, including hydrocodone bitartrate and acetaminophen tablets.
Source: FDA structured product labeling (set_id ee248dfd-7aa7-7dcc-e053-2995a90af19f).
Buprenorphine Naloxone
Opioid dependence treatment
Brands: Suboxone, Zubsolv
View Buprenorphine Naloxone safety profileHydrocodone Acetaminophen
Opioid analgesic combination
Brands: Norco, Vicodin, Lortab
View Hydrocodone Acetaminophen safety profileCheck these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Buprenorphine Naloxone and Hydrocodone Acetaminophen together?
Buprenorphine Naloxone and Hydrocodone Acetaminophen have a documented major interaction. The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.
How serious is the Buprenorphine Naloxone and Hydrocodone Acetaminophen interaction?
It is classified as a major interaction, based on the FDA label's warnings section (keywords: avoid). A major interaction can cause serious harm and often calls for a change in therapy or close monitoring.
What should I do if I'm taking both Buprenorphine Naloxone and Hydrocodone Acetaminophen?
If you have been prescribed both Buprenorphine Naloxone and Hydrocodone Acetaminophen, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Buprenorphine Naloxone Interactions
- Buprenorphine Naloxone + Naltrexone(contraindicated)
- Buprenorphine Naloxone + Codeine(major)
- Buprenorphine Naloxone + Morphine(major)
- Buprenorphine Naloxone + Oxycodone(major)
- Buprenorphine Naloxone + Tramadol(major)
- Buprenorphine Naloxone + Gabapentin(moderate)
- Buprenorphine Naloxone + Itraconazole(moderate)
- Buprenorphine Naloxone + Alprazolam(minor)
- Buprenorphine Naloxone + Carbamazepine(minor)
- Buprenorphine Naloxone + Cyclobenzaprine(minor)
- Buprenorphine Naloxone + Ketoconazole(minor)
- Buprenorphine Naloxone + Mirtazapine(minor)
- Buprenorphine Naloxone + Phenytoin(minor)
- Buprenorphine Naloxone + Pregabalin(minor)
- Buprenorphine Naloxone + Rifampin(minor)
- Buprenorphine Naloxone + Trazodone(minor)