Does Buprenorphine Naloxone Interact With Gabapentin?
7 DRUG INTERACTIONS Concentrations increased by morphine; may need dose adjustment (5.4, 7.1 ) 7.1 Opioids Respiratory depression and sedation, sometimes resulting in death, have been reported following coadministration of gabapentin with opioids (e.g., morphine, hydrocodone, oxycodone, buprenorphine) [ see Warnings and Precautions (5.7) ].
Severity: Moderate
Severity basis: drug interactions section (keywords: caution). Combining Buprenorphine Naloxone (Opioid dependence treatment) and Gabapentin (Gabapentinoid anticonvulsant) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Buprenorphine Naloxone is a opioid dependence treatment and Gabapentin is a gabapentinoid anticonvulsant; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Buprenorphine Naloxone and Gabapentin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
7 DRUG INTERACTIONS Concentrations increased by morphine; may need dose adjustment (5.4, 7.1 ) 7.1 Opioids Respiratory depression and sedation, sometimes resulting in death, have been reported following coadministration of gabapentin with opioids (e.g., morphine, hydrocodone, oxycodone, buprenorphine) [ see Warnings and Precautions (5.7) ].
Source: FDA structured product labeling (set_id 01b810b7-f4c8-4412-bbc5-b9220d8770d8).
Buprenorphine Naloxone
Opioid dependence treatment
Brands: Suboxone, Zubsolv
View Buprenorphine Naloxone safety profileCheck these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Buprenorphine Naloxone and Gabapentin together?
Buprenorphine Naloxone and Gabapentin have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How serious is the Buprenorphine Naloxone and Gabapentin interaction?
It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: caution). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.
What should I do if I'm taking both Buprenorphine Naloxone and Gabapentin?
If you have been prescribed both Buprenorphine Naloxone and Gabapentin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Buprenorphine Naloxone Interactions
- Buprenorphine Naloxone + Naltrexone(contraindicated)
- Buprenorphine Naloxone + Codeine(major)
- Buprenorphine Naloxone + Hydrocodone Acetaminophen(major)
- Buprenorphine Naloxone + Morphine(major)
- Buprenorphine Naloxone + Oxycodone(major)
- Buprenorphine Naloxone + Tramadol(major)
- Buprenorphine Naloxone + Itraconazole(moderate)
- Buprenorphine Naloxone + Alprazolam(minor)
- Buprenorphine Naloxone + Carbamazepine(minor)
- Buprenorphine Naloxone + Cyclobenzaprine(minor)
- Buprenorphine Naloxone + Ketoconazole(minor)
- Buprenorphine Naloxone + Mirtazapine(minor)
- Buprenorphine Naloxone + Phenytoin(minor)
- Buprenorphine Naloxone + Pregabalin(minor)
- Buprenorphine Naloxone + Rifampin(minor)
- Buprenorphine Naloxone + Trazodone(minor)
Other Gabapentin Interactions
- Gabapentin + Hydrocodone Acetaminophen(moderate)
- Gabapentin + Morphine(moderate)
- Gabapentin + Oxycodone(moderate)
- Gabapentin + Carbamazepine(minor)
- Gabapentin + Codeine(minor)
- Gabapentin + Estradiol(minor)
- Gabapentin + Naproxen(minor)
- Gabapentin + Phenytoin(minor)
- Gabapentin + Tramadol(minor)
- Gabapentin + Valproic Acid(minor)