Does Buprenorphine Naloxone Interact With Gabapentin?

7 DRUG INTERACTIONS Concentrations increased by morphine; may need dose adjustment (5.4, 7.1 ) 7.1 Opioids Respiratory depression and sedation, sometimes resulting in death, have been reported following coadministration of gabapentin with opioids (e.g., morphine, hydrocodone, oxycodone, buprenorphine) [ see Warnings and Precautions (5.7) ].

Severity: Moderate

Severity basis: drug interactions section (keywords: caution). Combining Buprenorphine Naloxone (Opioid dependence treatment) and Gabapentin (Gabapentinoid anticonvulsant) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

7 DRUG INTERACTIONS Concentrations increased by morphine; may need dose adjustment (5.4, 7.1 ) 7.1 Opioids Respiratory depression and sedation, sometimes resulting in death, have been reported following coadministration of gabapentin with opioids (e.g., morphine, hydrocodone, oxycodone, buprenorphine) [ see Warnings and Precautions (5.7) ].

Source: FDA structured product labeling (set_id 01b810b7-f4c8-4412-bbc5-b9220d8770d8).

Buprenorphine Naloxone

Opioid dependence treatment

Brands: Suboxone, Zubsolv

View Buprenorphine Naloxone safety profile

Gabapentin

Gabapentinoid anticonvulsant

Brands: Neurontin, Gralise

View Gabapentin safety profile

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This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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