Does Naltrexone Interact With Tramadol?
To prevent occurrence of precipitated withdrawal in patients dependent on opioids, or exacerbation of a pre-existing subclinical withdrawal syndrome, opioid-dependent patients, including those being treated for alcohol dependence, should be opioid-free (including tramadol) before starting naltrexone hydrochloride treatment.
Severity: Minor
Severity basis: warnings section. Combining Naltrexone (Opioid antagonist) and Tramadol (Opioid analgesic) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
To prevent occurrence of precipitated withdrawal in patients dependent on opioids, or exacerbation of a pre-existing subclinical withdrawal syndrome, opioid-dependent patients, including those being treated for alcohol dependence, should be opioid-free (including tramadol) before starting naltrexone hydrochloride treatment.
Source: FDA structured product labeling (set_id 00c04ff4-b6f2-466c-9ab9-813a60577db0).
Check these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Naltrexone Interactions
Other Tramadol Interactions
- Tramadol + Buprenorphine Naloxone(major)
- Tramadol + Carbamazepine(moderate)
- Tramadol + Fluoxetine(moderate)
- Tramadol + Ketoconazole(moderate)
- Tramadol + Ondansetron(moderate)
- Tramadol + Phenytoin(moderate)
- Tramadol + Rifampin(moderate)
- Tramadol + Alprazolam(minor)
- Tramadol + Amiodarone(minor)
- Tramadol + Amphetamine Dextroamphetamine(minor)
- Tramadol + Bupropion(minor)
- Tramadol + Citalopram(minor)
- Tramadol + Codeine(minor)
- Tramadol + Cyclobenzaprine(minor)
- Tramadol + Desvenlafaxine(minor)
- Tramadol + Digoxin(minor)
- Tramadol + Duloxetine(minor)
- Tramadol + Escitalopram(minor)
- Tramadol + Gabapentin(minor)
- Tramadol + Lisdexamfetamine(minor)
- Tramadol + Lithium(minor)
- Tramadol + Mirtazapine(minor)
- Tramadol + Morphine(minor)
- Tramadol + Nortriptyline(minor)
- Tramadol + Oxycodone(minor)
- Tramadol + Paroxetine(minor)
- Tramadol + Pregabalin(minor)
- Tramadol + Sertraline(minor)
- Tramadol + Trazodone(minor)
- Tramadol + Venlafaxine(minor)
- Tramadol + Warfarin(minor)