Does Buprenorphine Naloxone Interact With Oxycodone?

Intervention: Avoid concomitant use Examples: Butorphanol, nalbuphine, pentazocine, buprenorphine Muscle Relaxants Clinical Impact: Oxycodone may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression.

Severity: Major

Severity basis: drug interactions section (keywords: avoid). Combining Buprenorphine Naloxone (Opioid dependence treatment) and Oxycodone (Opioid analgesic) is classified as a major interaction.

What to Do

The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.

From the FDA Label

Intervention: Avoid concomitant use Examples: Butorphanol, nalbuphine, pentazocine, buprenorphine Muscle Relaxants Clinical Impact: Oxycodone may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression.

Source: FDA structured product labeling (set_id 01db4606-d49c-4b10-a78a-1cf41880a9fb).

Buprenorphine Naloxone

Opioid dependence treatment

Brands: Suboxone, Zubsolv

View Buprenorphine Naloxone safety profile

Oxycodone

Opioid analgesic

Brands: OxyContin, Roxicodone, Percocet

View Oxycodone safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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