Does Carbidopa Levodopa Interact With Ferrous Sulfate?
7 DRUG INTERACTIONS Drugs metabolized by COMT: use with caution ( 5.11 , 7.2 ) Anti-hypertensive agents: dose adjustment may be required ( 7.3 ) Tricyclic antidepressants: risk of hypertension and dyskinesia reported during concomitant use with carbidopa/levodopa ( 7.4 ) Dopamine D2 receptor antagonists, isoniazid, phenytoin, papaverine and iron salts: may reduce efficacy of carbidopa, levodopa and entacapone tablets ( 7.5 , 7.6 , 7.7 , 7.8 , 7.9 ) Drugs that interfere with biliary excretion,…
Severity: Moderate
Severity basis: drug interactions section (keywords: monitor, caution, may reduce). Combining Carbidopa Levodopa (Antiparkinson agent) and Ferrous Sulfate (Oral iron supplement) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
From the FDA Label
7 DRUG INTERACTIONS Drugs metabolized by COMT: use with caution ( 5.11 , 7.2 ) Anti-hypertensive agents: dose adjustment may be required ( 7.3 ) Tricyclic antidepressants: risk of hypertension and dyskinesia reported during concomitant use with carbidopa/levodopa ( 7.4 ) Dopamine D2 receptor antagonists, isoniazid, phenytoin, papaverine and iron salts: may reduce efficacy of carbidopa, levodopa and entacapone tablets ( 7.5 , 7.6 , 7.7 , 7.8 , 7.9 ) Drugs that interfere with biliary excretion,…
Source: FDA structured product labeling (set_id 2f8e82d7-6baf-456a-b8c3-4fda6e317902).
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Carbidopa Levodopa Interactions
- Carbidopa Levodopa + Metoclopramide(moderate)
- Carbidopa Levodopa + Phenytoin(moderate)
- Carbidopa Levodopa + Risperidone(moderate)
- Carbidopa Levodopa + Warfarin(moderate)
- Carbidopa Levodopa + Bupropion(minor)
- Carbidopa Levodopa + Olanzapine(minor)
- Carbidopa Levodopa + Quetiapine(minor)
- Carbidopa Levodopa + Rifampin(minor)