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    HomeMedication GuideDrug InteractionsCarbidopa Levodopa + Warfarin
    Moderate interaction

    Does Carbidopa Levodopa Interact With Warfarin?

    7 DRUG INTERACTIONS Drugs metabolized by COMT: use with caution ( 5.11 , 7.2 ) Anti-hypertensive agents: dose adjustment may be required ( 7.3 ) Tricyclic antidepressants: risk of hypertension and dyskinesia reported during concomitant use with carbidopa/levodopa ( 7.4 ) Dopamine D2 receptor antagonists, isoniazid, phenytoin, papaverine and iron salts: may reduce efficacy of carbidopa, levodopa and entacapone tablets ( 7.5 , 7.6 , 7.7 , 7.8 , 7.9 ) Drugs that interfere with biliary excretion,…

    Reviewed by the OmniRx Health clinical team•Last reviewed Jul 4, 2026

    Severity: Moderate

    Severity basis: drug interactions section (keywords: monitor, caution, may reduce). Combining Carbidopa Levodopa (Antiparkinson agent) and Warfarin (Vitamin K antagonist anticoagulant) is classified as a moderate interaction.

    What to Do

    Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

    How This Interaction Works

    Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Carbidopa Levodopa is a antiparkinson agent and Warfarin is a vitamin k antagonist anticoagulant; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.

    If You Take Both Medications

    If you have been prescribed both Carbidopa Levodopa and Warfarin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

    From the FDA Label

    7 DRUG INTERACTIONS Drugs metabolized by COMT: use with caution ( 5.11 , 7.2 ) Anti-hypertensive agents: dose adjustment may be required ( 7.3 ) Tricyclic antidepressants: risk of hypertension and dyskinesia reported during concomitant use with carbidopa/levodopa ( 7.4 ) Dopamine D2 receptor antagonists, isoniazid, phenytoin, papaverine and iron salts: may reduce efficacy of carbidopa, levodopa and entacapone tablets ( 7.5 , 7.6 , 7.7 , 7.8 , 7.9 ) Drugs that interfere with biliary excretion,…

    Source: FDA structured product labeling (set_id 2f8e82d7-6baf-456a-b8c3-4fda6e317902).

    Carbidopa Levodopa

    Antiparkinson agent

    Brands: Sinemet, Rytary

    View Carbidopa Levodopa safety profile

    Warfarin

    Vitamin K antagonist anticoagulant

    Brands: Coumadin, Jantoven

    View Warfarin safety profile

    Check these against your full medication list in our free Interaction Checker

    Frequently Asked Questions

    Can you take Carbidopa Levodopa and Warfarin together?

    Carbidopa Levodopa and Warfarin have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

    How serious is the Carbidopa Levodopa and Warfarin interaction?

    It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: monitor, caution, may reduce). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.

    What should I do if I'm taking both Carbidopa Levodopa and Warfarin?

    If you have been prescribed both Carbidopa Levodopa and Warfarin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

    Questions About Your Medications?

    A licensed OmniRx provider can review your full medication list and help you understand what's safe for you — no office visit required.

    Other Warfarin Interactions

    Sources & References

    Learn more about where our data comes from and how we write and review medical content.