Does Carbidopa Levodopa Interact With Metoclopramide?
7.5 Dopamine D2 Receptor Antagonists Dopamine D2 receptor antagonists (e.g., metoclopramide, phenothiazines, butyrophenones, risperidone) may reduce the therapeutic effects of levodopa.
Severity: Moderate
Severity basis: drug interactions section (keywords: may reduce). Combining Carbidopa Levodopa (Antiparkinson agent) and Metoclopramide (Prokinetic / antiemetic) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
From the FDA Label
7.5 Dopamine D2 Receptor Antagonists Dopamine D2 receptor antagonists (e.g., metoclopramide, phenothiazines, butyrophenones, risperidone) may reduce the therapeutic effects of levodopa.
Source: FDA structured product labeling (set_id 2f8e82d7-6baf-456a-b8c3-4fda6e317902).
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Carbidopa Levodopa Interactions
- Carbidopa Levodopa + Ferrous Sulfate(moderate)
- Carbidopa Levodopa + Phenytoin(moderate)
- Carbidopa Levodopa + Risperidone(moderate)
- Carbidopa Levodopa + Warfarin(moderate)
- Carbidopa Levodopa + Bupropion(minor)
- Carbidopa Levodopa + Olanzapine(minor)
- Carbidopa Levodopa + Quetiapine(minor)
- Carbidopa Levodopa + Rifampin(minor)