Does Carbidopa Levodopa Interact With Metoclopramide?
7.5 Dopamine D2 Receptor Antagonists Dopamine D2 receptor antagonists (e.g., metoclopramide, phenothiazines, butyrophenones, risperidone) may reduce the therapeutic effects of levodopa.
Severity: Moderate
Severity basis: drug interactions section (keywords: may reduce). Combining Carbidopa Levodopa (Antiparkinson agent) and Metoclopramide (Prokinetic / antiemetic) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Carbidopa Levodopa is a antiparkinson agent and Metoclopramide is a prokinetic / antiemetic; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Carbidopa Levodopa and Metoclopramide, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
7.5 Dopamine D2 Receptor Antagonists Dopamine D2 receptor antagonists (e.g., metoclopramide, phenothiazines, butyrophenones, risperidone) may reduce the therapeutic effects of levodopa.
Source: FDA structured product labeling (set_id 2f8e82d7-6baf-456a-b8c3-4fda6e317902).
Check these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Carbidopa Levodopa and Metoclopramide together?
Carbidopa Levodopa and Metoclopramide have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How serious is the Carbidopa Levodopa and Metoclopramide interaction?
It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: may reduce). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.
What should I do if I'm taking both Carbidopa Levodopa and Metoclopramide?
If you have been prescribed both Carbidopa Levodopa and Metoclopramide, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Carbidopa Levodopa Interactions
- Carbidopa Levodopa + Ferrous Sulfate(moderate)
- Carbidopa Levodopa + Phenytoin(moderate)
- Carbidopa Levodopa + Risperidone(moderate)
- Carbidopa Levodopa + Warfarin(moderate)
- Carbidopa Levodopa + Bupropion(minor)
- Carbidopa Levodopa + Olanzapine(minor)
- Carbidopa Levodopa + Quetiapine(minor)
- Carbidopa Levodopa + Rifampin(minor)