Does Carbidopa Levodopa Interact With Risperidone?

7.5 Dopamine D2 Receptor Antagonists Dopamine D2 receptor antagonists (e.g., metoclopramide, phenothiazines, butyrophenones, risperidone) may reduce the therapeutic effects of levodopa.

Severity: Moderate

Severity basis: drug interactions section (keywords: may reduce). Combining Carbidopa Levodopa (Antiparkinson agent) and Risperidone (Atypical antipsychotic) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

7.5 Dopamine D2 Receptor Antagonists Dopamine D2 receptor antagonists (e.g., metoclopramide, phenothiazines, butyrophenones, risperidone) may reduce the therapeutic effects of levodopa.

Source: FDA structured product labeling (set_id 2f8e82d7-6baf-456a-b8c3-4fda6e317902).

Carbidopa Levodopa

Antiparkinson agent

Brands: Sinemet, Rytary

View Carbidopa Levodopa safety profile

Risperidone

Atypical antipsychotic

Brands: Risperdal

View Risperidone safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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