Does Clonazepam Interact With Fluconazole?
Although clinical studies have not been performed, based on the involvement of the cytochrome P-450 3A family in clonazepam metabolism, inhibitors of this enzyme system, notably oral antifungal agents (e.g., fluconazole), should be used cautiously in patients receiving clonazepam because they may impair the metabolism of clonazepam leading to exaggerated concentrations and effects.
Severity: Minor
Severity basis: drug interactions section. Combining Clonazepam (Benzodiazepine) and Fluconazole (Azole antifungal) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
Although clinical studies have not been performed, based on the involvement of the cytochrome P-450 3A family in clonazepam metabolism, inhibitors of this enzyme system, notably oral antifungal agents (e.g., fluconazole), should be used cautiously in patients receiving clonazepam because they may impair the metabolism of clonazepam leading to exaggerated concentrations and effects.
Source: FDA structured product labeling (set_id 00f323c0-e007-40df-ae7f-e6b3c7ba0aa8).
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Clonazepam Interactions
Other Fluconazole Interactions
- Fluconazole + Clarithromycin(major)
- Fluconazole + Rifampin(major)
- Fluconazole + Amiodarone(moderate)
- Fluconazole + Cyclosporine(moderate)
- Fluconazole + Glimepiride(moderate)
- Fluconazole + Glipizide(moderate)
- Fluconazole + Glyburide(moderate)
- Fluconazole + Phenytoin(moderate)
- Fluconazole + Tacrolimus(moderate)
- Fluconazole + Warfarin(moderate)
- Fluconazole + Amitriptyline(minor)
- Fluconazole + Amlodipine(minor)
- Fluconazole + Atorvastatin(minor)
- Fluconazole + Azithromycin(minor)
- Fluconazole + Carbamazepine(minor)
- Fluconazole + Carvedilol(minor)
- Fluconazole + Celecoxib(minor)
- Fluconazole + Diclofenac(minor)
- Fluconazole + Estradiol(minor)
- Fluconazole + Hydrochlorothiazide(minor)
- Fluconazole + Ibuprofen(minor)
- Fluconazole + Losartan(minor)
- Fluconazole + Meloxicam(minor)
- Fluconazole + Naproxen(minor)
- Fluconazole + Nifedipine(minor)
- Fluconazole + Nortriptyline(minor)
- Fluconazole + Prednisone(minor)
- Fluconazole + Simvastatin(minor)
- Fluconazole + Verapamil(minor)