Does Diltiazem Interact With Lovastatin?

In a ten-subject randomized, open-label, 4-way crossover study, coadministration of diltiazem (120 mg BID diltiazem SR for 2 weeks) with a single 20 mg dose of lovastatin resulted in 3- to 4-fold increase in mean lovastatin AUC and C max versus lovastatin alone.

Severity: Minor

Severity basis: drug interactions section. Combining Diltiazem (Calcium channel blocker) and Lovastatin (HMG-CoA reductase inhibitor (statin)) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

In a ten-subject randomized, open-label, 4-way crossover study, coadministration of diltiazem (120 mg BID diltiazem SR for 2 weeks) with a single 20 mg dose of lovastatin resulted in 3- to 4-fold increase in mean lovastatin AUC and C max versus lovastatin alone.

Source: FDA structured product labeling (set_id 0089fc7a-a7aa-4873-b699-39a1b21616ca).

Diltiazem

Calcium channel blocker

Brands: Cardizem, Cartia XT, Tiazac

View Diltiazem safety profile

Lovastatin

HMG-CoA reductase inhibitor (statin)

Brands: Mevacor, Altoprev

View Lovastatin safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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