Does Amiodarone Interact With Lovastatin?

Name: Does Amiodarone Interact With Lovastatin?
Creator: OmniRx Health

Amiodarone The risk of myopathy/rhabdomyolysis is increased when amiodarone is used concomitantly with a closely related member of the HMG-CoA reductase inhibitor class (see WARNINGS , Myopathy/Rhabdomyolysis ).

Reviewed by the OmniRx Health clinical team•Last reviewed Jul 4, 2026

Severity: Moderate

Severity basis: drug interactions section (keywords: closely). Combining Amiodarone (Class III antiarrhythmic) and Lovastatin (HMG-CoA reductase inhibitor (statin)) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

How This Interaction Works

Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Amiodarone is a class iii antiarrhythmic and Lovastatin is a hmg-coa reductase inhibitor (statin); together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.

If You Take Both Medications

If you have been prescribed both Amiodarone and Lovastatin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

From the FDA Label

Amiodarone The risk of myopathy/rhabdomyolysis is increased when amiodarone is used concomitantly with a closely related member of the HMG-CoA reductase inhibitor class (see WARNINGS , Myopathy/Rhabdomyolysis ).

Source: FDA structured product labeling (set_id 027bd594-6a0a-4e6d-bd3c-4f33fdb4166a).

Amiodarone

Class III antiarrhythmic

Brands: Pacerone, Cordarone

View Amiodarone safety profile

Lovastatin

HMG-CoA reductase inhibitor (statin)

Brands: Mevacor, Altoprev

View Lovastatin safety profile

Check these against your full medication list in our free Interaction Checker

Frequently Asked Questions

Can you take Amiodarone and Lovastatin together?

Amiodarone and Lovastatin have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

How serious is the Amiodarone and Lovastatin interaction?

It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: closely). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.

What should I do if I'm taking both Amiodarone and Lovastatin?

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

Questions About Your Medications?

A licensed OmniRx provider can review your full medication list and help you understand what's safe for you — no office visit required.

Other Amiodarone Interactions

Other Lovastatin Interactions

Sources & References

Learn more about where our data comes from and how we write and review medical content.