Does Amiodarone Interact With Lovastatin?

Amiodarone The risk of myopathy/rhabdomyolysis is increased when amiodarone is used concomitantly with a closely related member of the HMG-CoA reductase inhibitor class (see WARNINGS , Myopathy/Rhabdomyolysis ).

Severity: Moderate

Severity basis: drug interactions section (keywords: closely). Combining Amiodarone (Class III antiarrhythmic) and Lovastatin (HMG-CoA reductase inhibitor (statin)) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Amiodarone The risk of myopathy/rhabdomyolysis is increased when amiodarone is used concomitantly with a closely related member of the HMG-CoA reductase inhibitor class (see WARNINGS , Myopathy/Rhabdomyolysis ).

Source: FDA structured product labeling (set_id 027bd594-6a0a-4e6d-bd3c-4f33fdb4166a).

Amiodarone

Class III antiarrhythmic

Brands: Pacerone, Cordarone

View Amiodarone safety profile

Lovastatin

HMG-CoA reductase inhibitor (statin)

Brands: Mevacor, Altoprev

View Lovastatin safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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