Does Duloxetine Interact With Nortriptyline?
Potential for Duloxetine delayed-release capsules to Affect Other Drugs Drugs Metabolized by CYP2D6 — Co-administration of Duloxetine delayed-release capsules with drugs that are extensively metabolized by CYP2D6 and that have a narrow therapeutic index, including certain antidepressants (tricyclic antidepressants [TCAs], such as nortriptyline, amitriptyline, and imipramine), phenothiazines and Type 1C antiarrhythmics (e.g., propafenone, flecainide), should be approached with caution.
Severity: Moderate
Severity basis: warnings section (keywords: caution). Combining Duloxetine (SNRI antidepressant) and Nortriptyline (Tricyclic antidepressant) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
From the FDA Label
Potential for Duloxetine delayed-release capsules to Affect Other Drugs Drugs Metabolized by CYP2D6 — Co-administration of Duloxetine delayed-release capsules with drugs that are extensively metabolized by CYP2D6 and that have a narrow therapeutic index, including certain antidepressants (tricyclic antidepressants [TCAs], such as nortriptyline, amitriptyline, and imipramine), phenothiazines and Type 1C antiarrhythmics (e.g., propafenone, flecainide), should be approached with caution.
Source: FDA structured product labeling (set_id 00628e5e-4c5b-2573-e063-6294a90a0e3b).
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Duloxetine Interactions
- Duloxetine + Amitriptyline(moderate)
- Duloxetine + Ciprofloxacin(moderate)
- Duloxetine + Fluoxetine(moderate)
- Duloxetine + Aspirin(minor)
- Duloxetine + Buspirone(minor)
- Duloxetine + Famotidine(minor)
- Duloxetine + Lithium(minor)
- Duloxetine + Lorazepam(minor)
- Duloxetine + Paroxetine(minor)
- Duloxetine + Temazepam(minor)
- Duloxetine + Tramadol(minor)
- Duloxetine + Warfarin(minor)