Does Duloxetine Interact With Fluoxetine?

Similar effects would be expected with other potent CYP2D6 inhibitors (e.g., fluoxetine, quinidine) [see Warnings and Precautions (5.12) ].

Severity: Moderate

Severity basis: drug interactions section (keywords: caution). Combining Duloxetine (SNRI antidepressant) and Fluoxetine (SSRI antidepressant) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Similar effects would be expected with other potent CYP2D6 inhibitors (e.g., fluoxetine, quinidine) [see Warnings and Precautions (5.12) ].

Source: FDA structured product labeling (set_id 00628e5e-4c5b-2573-e063-6294a90a0e3b).

Duloxetine

SNRI antidepressant

Brands: Cymbalta

View Duloxetine safety profile

Fluoxetine

SSRI antidepressant

Brands: Prozac, Sarafem

View Fluoxetine safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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