Does Duloxetine Interact With Paroxetine?
7.2 Inhibitors of CYP2D6 Concomitant use of duloxetine (40 mg once daily) with paroxetine (20 mg once daily) increased the concentration of duloxetine AUC by about 60%, and greater degrees of inhibition are expected with higher doses of paroxetine.
Severity: Minor
Severity basis: drug interactions section. Combining Duloxetine (SNRI antidepressant) and Paroxetine (SSRI antidepressant) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
7.2 Inhibitors of CYP2D6 Concomitant use of duloxetine (40 mg once daily) with paroxetine (20 mg once daily) increased the concentration of duloxetine AUC by about 60%, and greater degrees of inhibition are expected with higher doses of paroxetine.
Source: FDA structured product labeling (set_id 00628e5e-4c5b-2573-e063-6294a90a0e3b).
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Duloxetine Interactions
- Duloxetine + Amitriptyline(moderate)
- Duloxetine + Ciprofloxacin(moderate)
- Duloxetine + Fluoxetine(moderate)
- Duloxetine + Nortriptyline(moderate)
- Duloxetine + Aspirin(minor)
- Duloxetine + Buspirone(minor)
- Duloxetine + Famotidine(minor)
- Duloxetine + Lithium(minor)
- Duloxetine + Lorazepam(minor)
- Duloxetine + Temazepam(minor)
- Duloxetine + Tramadol(minor)
- Duloxetine + Warfarin(minor)
Other Paroxetine Interactions
- Paroxetine + Aripiprazole(moderate)
- Paroxetine + Aspirin(moderate)
- Paroxetine + Atomoxetine(moderate)
- Paroxetine + Phenytoin(moderate)
- Paroxetine + Tamsulosin(moderate)
- Paroxetine + Warfarin(moderate)
- Paroxetine + Amitriptyline(minor)
- Paroxetine + Bupropion(minor)
- Paroxetine + Buspirone(minor)
- Paroxetine + Carvedilol(minor)
- Paroxetine + Clopidogrel(minor)
- Paroxetine + Codeine(minor)
- Paroxetine + Lithium(minor)
- Paroxetine + Metoprolol(minor)
- Paroxetine + Risperidone(minor)
- Paroxetine + Sertraline(minor)
- Paroxetine + Tramadol(minor)
- Paroxetine + Venlafaxine(minor)