Does Ciprofloxacin Interact With Duloxetine?
Other drugs that inhibit CYP1A2 metabolism include cimetidine and quinolone antimicrobials such as ciprofloxacin and enoxacin [see Warnings and Precautions (5.12) ].
Severity: Moderate
Severity basis: drug interactions section (keywords: caution). Combining Ciprofloxacin (Fluoroquinolone antibiotic) and Duloxetine (SNRI antidepressant) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Ciprofloxacin is a fluoroquinolone antibiotic and Duloxetine is a snri antidepressant; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Ciprofloxacin and Duloxetine, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
Other drugs that inhibit CYP1A2 metabolism include cimetidine and quinolone antimicrobials such as ciprofloxacin and enoxacin [see Warnings and Precautions (5.12) ].
Source: FDA structured product labeling (set_id 00628e5e-4c5b-2573-e063-6294a90a0e3b).
Check these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Ciprofloxacin and Duloxetine together?
Ciprofloxacin and Duloxetine have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How serious is the Ciprofloxacin and Duloxetine interaction?
It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: caution). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.
What should I do if I'm taking both Ciprofloxacin and Duloxetine?
If you have been prescribed both Ciprofloxacin and Duloxetine, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Ciprofloxacin Interactions
Other Duloxetine Interactions
- Duloxetine + Amitriptyline(moderate)
- Duloxetine + Fluoxetine(moderate)
- Duloxetine + Nortriptyline(moderate)
- Duloxetine + Aspirin(minor)
- Duloxetine + Buspirone(minor)
- Duloxetine + Famotidine(minor)
- Duloxetine + Lithium(minor)
- Duloxetine + Lorazepam(minor)
- Duloxetine + Paroxetine(minor)
- Duloxetine + Temazepam(minor)
- Duloxetine + Tramadol(minor)
- Duloxetine + Warfarin(minor)