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    HomeMedication GuideDrug InteractionsCiprofloxacin + Duloxetine
    Moderate interaction

    Does Ciprofloxacin Interact With Duloxetine?

    Other drugs that inhibit CYP1A2 metabolism include cimetidine and quinolone antimicrobials such as ciprofloxacin and enoxacin [see Warnings and Precautions (5.12) ].

    Severity: Moderate

    Severity basis: drug interactions section (keywords: caution). Combining Ciprofloxacin (Fluoroquinolone antibiotic) and Duloxetine (SNRI antidepressant) is classified as a moderate interaction.

    What to Do

    Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

    From the FDA Label

    Other drugs that inhibit CYP1A2 metabolism include cimetidine and quinolone antimicrobials such as ciprofloxacin and enoxacin [see Warnings and Precautions (5.12) ].

    Source: FDA structured product labeling (set_id 00628e5e-4c5b-2573-e063-6294a90a0e3b).

    Ciprofloxacin

    Fluoroquinolone antibiotic

    Brands: Cipro

    View Ciprofloxacin safety profile

    Duloxetine

    SNRI antidepressant

    Brands: Cymbalta

    View Duloxetine safety profile

    Check these against your full medication list in our free Interaction Checker

    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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