Does Isosorbide Mononitrate Interact With Tadalafil?

Do not use isosorbide mononitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil.

Severity: Contraindicated

Severity basis: contraindications section (keywords: do not use). Combining Isosorbide Mononitrate (Nitrate vasodilator) and Tadalafil (PDE5 inhibitor) is classified as a contraindicated interaction.

What to Do

This combination is contraindicated on the FDA label. Do not take these together unless your prescriber explicitly directs it.

From the FDA Label

Do not use isosorbide mononitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil.

Source: FDA structured product labeling (set_id 06839534-85b8-42aa-b0e3-079ed236be44).

Isosorbide Mononitrate

Nitrate vasodilator

Brands: Imdur

View Isosorbide Mononitrate safety profile

Tadalafil

PDE5 inhibitor

Brands: Cialis, Adcirca

View Tadalafil safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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Other Isosorbide Mononitrate Interactions

Isosorbide Mononitrate + Sildenafil(contraindicated)