Does Itraconazole Interact With Tadalafil?
Aliskiren a Riociguat Sildenafil (for pulmonary hypertension) Tadalafil (for pulmonary hypertension) Not recommended during and 2 weeks after itraconazole treatment.
Severity: Major
Severity basis: drug interactions section (keywords: not recommended). Combining Itraconazole (Azole antifungal (strong CYP3A4 inhibitor)) and Tadalafil (PDE5 inhibitor) is classified as a major interaction.
What to Do
The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Itraconazole is a azole antifungal (strong cyp3a4 inhibitor) and Tadalafil is a pde5 inhibitor; together they are documented as a major interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Itraconazole and Tadalafil, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
Aliskiren a Riociguat Sildenafil (for pulmonary hypertension) Tadalafil (for pulmonary hypertension) Not recommended during and 2 weeks after itraconazole treatment.
Source: FDA structured product labeling (set_id 23126370-8d6a-4027-bd8f-860e2776ba3a).
Itraconazole
Azole antifungal (strong CYP3A4 inhibitor)
Brands: Sporanox, Tolsura
View Itraconazole safety profileCheck these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Itraconazole and Tadalafil together?
Itraconazole and Tadalafil have a documented major interaction. The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.
How serious is the Itraconazole and Tadalafil interaction?
It is classified as a major interaction, based on the FDA label's drug interactions section (keywords: not recommended). A major interaction can cause serious harm and often calls for a change in therapy or close monitoring.
What should I do if I'm taking both Itraconazole and Tadalafil?
If you have been prescribed both Itraconazole and Tadalafil, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Itraconazole Interactions
- Itraconazole + Colchicine(contraindicated)
- Itraconazole + Lovastatin(contraindicated)
- Itraconazole + Simvastatin(contraindicated)
- Itraconazole + Ticagrelor(contraindicated)
- Itraconazole + Apixaban(major)
- Itraconazole + Carbamazepine(major)
- Itraconazole + Fluticasone Salmeterol(major)
- Itraconazole + Phenytoin(major)
- Itraconazole + Rifampin(major)
- Itraconazole + Rivaroxaban(major)
- Itraconazole + Sildenafil(major)
- Itraconazole + Tamsulosin(major)
- Itraconazole + Trazodone(major)
- Itraconazole + Alprazolam(moderate)
- Itraconazole + Aripiprazole(moderate)
- Itraconazole + Atorvastatin(moderate)
- Itraconazole + Budesonide(moderate)
- Itraconazole + Buprenorphine Naloxone(moderate)
- Itraconazole + Buspirone(moderate)
- Itraconazole + Ciprofloxacin(moderate)
- Itraconazole + Clarithromycin(moderate)
- Itraconazole + Cyclosporine(moderate)
- Itraconazole + Dabigatran(moderate)
- Itraconazole + Dexamethasone(moderate)
- Itraconazole + Diazepam(moderate)
- Itraconazole + Digoxin(moderate)
- Itraconazole + Diltiazem(moderate)
- Itraconazole + Fluticasone(moderate)
- Itraconazole + Methylprednisolone(moderate)
- Itraconazole + Mirtazapine(moderate)
- Itraconazole + Oxybutynin(moderate)
- Itraconazole + Oxycodone(moderate)
- Itraconazole + Quetiapine(moderate)
- Itraconazole + Risperidone(moderate)
- Itraconazole + Tacrolimus(moderate)
- Itraconazole + Venlafaxine(moderate)
- Itraconazole + Verapamil(moderate)
- Itraconazole + Warfarin(moderate)
- Itraconazole + Eszopiclone(minor)
- Itraconazole + Famotidine(minor)
- Itraconazole + Ketoconazole(minor)
- Itraconazole + Lansoprazole(minor)
- Itraconazole + Meloxicam(minor)
- Itraconazole + Montelukast(minor)
- Itraconazole + Pantoprazole(minor)
Other Tadalafil Interactions
- Tadalafil + Isosorbide Mononitrate(contraindicated)
- Tadalafil + Nitroglycerin(contraindicated)
- Tadalafil + Carbamazepine(moderate)
- Tadalafil + Clarithromycin(moderate)
- Tadalafil + Amlodipine(minor)
- Tadalafil + Aspirin(minor)
- Tadalafil + Digoxin(minor)
- Tadalafil + Enalapril(minor)
- Tadalafil + Ketoconazole(minor)
- Tadalafil + Lovastatin(minor)
- Tadalafil + Metoprolol(minor)
- Tadalafil + Phenytoin(minor)
- Tadalafil + Rifampin(minor)
- Tadalafil + Tamsulosin(minor)
- Tadalafil + Warfarin(minor)