Does Enalapril Interact With Tadalafil?

Clinical pharmacology studies were conducted to assess the effect of tadalafil on the potentiation of the blood-pressure-lowering effects of selected antihypertensive medications (amlodipine, angiotensin II receptor blockers, bendrofluazide, enalapril, and metoprolol).

Severity: Minor

Severity basis: drug interactions section. Combining Enalapril (ACE inhibitor) and Tadalafil (PDE5 inhibitor) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Clinical pharmacology studies were conducted to assess the effect of tadalafil on the potentiation of the blood-pressure-lowering effects of selected antihypertensive medications (amlodipine, angiotensin II receptor blockers, bendrofluazide, enalapril, and metoprolol).

Source: FDA structured product labeling (set_id 00cbc656-768d-4995-bb6d-a0d4b32a248c).

Enalapril

ACE inhibitor

Brands: Vasotec

View Enalapril safety profile

Tadalafil

PDE5 inhibitor

Brands: Cialis, Adcirca

View Tadalafil safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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