Does Ketoconazole Interact With Oxybutynin?

Mean oxybutynin chloride plasma concentrations were approximately 2 fold higher when Oxybutynin chloride extended-release tablets were administered with ketoconazole, a potent CYP3A4 inhibitor.

Severity: Minor

Severity basis: drug interactions section. Combining Ketoconazole (Azole antifungal (strong CYP3A4 inhibitor)) and Oxybutynin (Anticholinergic (overactive bladder)) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Mean oxybutynin chloride plasma concentrations were approximately 2 fold higher when Oxybutynin chloride extended-release tablets were administered with ketoconazole, a potent CYP3A4 inhibitor.

Source: FDA structured product labeling (set_id 02ff3be7-fc5c-4b91-8c67-ecdf6e19c42a).

Ketoconazole

Azole antifungal (strong CYP3A4 inhibitor)

Brands: Nizoral

View Ketoconazole safety profile

Oxybutynin

Anticholinergic (overactive bladder)

Brands: Ditropan, Oxytrol

View Oxybutynin safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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