Does Metoclopramide Interact With Oxybutynin?
Anticholinergic agents may also antagonize the effects of prokinetic agents, such as metoclopramide.
Severity: Minor
Severity basis: drug interactions section. Combining Metoclopramide (Prokinetic / antiemetic) and Oxybutynin (Anticholinergic (overactive bladder)) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
Anticholinergic agents may also antagonize the effects of prokinetic agents, such as metoclopramide.
Source: FDA structured product labeling (set_id 02ff3be7-fc5c-4b91-8c67-ecdf6e19c42a).
Oxybutynin
Anticholinergic (overactive bladder)
Brands: Ditropan, Oxytrol
View Oxybutynin safety profileCheck these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.