Does Clarithromycin Interact With Oxybutynin?

Other inhibitors of the cytochrome P450 3A4 enzyme system, such as antimycotic agents (e.g., itraconazole and miconazole) or macrolide antibiotics (e.g., erythromycin and clarithromycin), may alter oxybutynin mean pharmacokinetic parameters (i.e., C max and AUC).

Severity: Minor

Severity basis: drug interactions section. Combining Clarithromycin (Macrolide antibiotic) and Oxybutynin (Anticholinergic (overactive bladder)) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Other inhibitors of the cytochrome P450 3A4 enzyme system, such as antimycotic agents (e.g., itraconazole and miconazole) or macrolide antibiotics (e.g., erythromycin and clarithromycin), may alter oxybutynin mean pharmacokinetic parameters (i.e., C max and AUC).

Source: FDA structured product labeling (set_id 02ff3be7-fc5c-4b91-8c67-ecdf6e19c42a).

Clarithromycin

Macrolide antibiotic

Brands: Biaxin

View Clarithromycin safety profile

Oxybutynin

Anticholinergic (overactive bladder)

Brands: Ditropan, Oxytrol

View Oxybutynin safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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