Does Itraconazole Interact With Ketoconazole?

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Itraconazole is a azole antifungal (strong cyp3a4 inhibitor) and Ketoconazole is a azole antifungal (strong cyp3a4 inhibitor); together they are documented as a minor interaction. How much this matters depends on your dose, your other medications, and your overall health.

If you have been prescribed both Itraconazole and Ketoconazole, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

Although many of the clinical drug interactions in Table 1 are based on information with a similar azole antifungal, ketoconazole, these interactions are expected to occur with itraconazole.

Source: FDA structured product labeling (set_id 23126370-8d6a-4027-bd8f-860e2776ba3a).