Does Atorvastatin Interact With Ketoconazole?

Examples: Erythromycin, clarithromycin, itraconazole, ketoconazole, posaconazole, and voriconazole.

Severity: Minor

Severity basis: drug interactions section. Combining Atorvastatin (HMG-CoA reductase inhibitor (statin)) and Ketoconazole (Azole antifungal (strong CYP3A4 inhibitor)) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Examples: Erythromycin, clarithromycin, itraconazole, ketoconazole, posaconazole, and voriconazole.

Source: FDA structured product labeling (set_id 00afce9b-48c9-487a-a738-e359c005c707).

Atorvastatin

HMG-CoA reductase inhibitor (statin)

Brands: Lipitor

View Atorvastatin safety profile

Ketoconazole

Azole antifungal (strong CYP3A4 inhibitor)

Brands: Nizoral

View Ketoconazole safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

Questions About Your Medications?

A licensed OmniRx provider can review your full medication list and help you understand what's safe for you — no office visit required.