Does Lithium Interact With Valsartan?

7 DRUG INTERACTIONS Potassium-sparing diuretics, potassium supplements or salt substitutes may lead to increases in serum potassium, and in heart failure patients, increases in serum creatinine ( 7.1 ) NSAID use may lead to increased risk of renal impairment and loss of antihypertensive effect ( 7.2 ) Dual inhibition of the renin-angiotensin system : Increased risk of renal impairment, hypotension, and hyperkalemia ( 7.3 ) Lithium : Increases in serum lithium level and lithium toxicity ( 7.4 …

Severity: Moderate

Severity basis: drug interactions section (keywords: increased risk, may increase). Combining Lithium (Mood stabilizer) and Valsartan (Angiotensin receptor blocker (ARB)) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

7 DRUG INTERACTIONS Potassium-sparing diuretics, potassium supplements or salt substitutes may lead to increases in serum potassium, and in heart failure patients, increases in serum creatinine ( 7.1 ) NSAID use may lead to increased risk of renal impairment and loss of antihypertensive effect ( 7.2 ) Dual inhibition of the renin-angiotensin system : Increased risk of renal impairment, hypotension, and hyperkalemia ( 7.3 ) Lithium : Increases in serum lithium level and lithium toxicity ( 7.4 …

Source: FDA structured product labeling (set_id 00b235b2-a909-4628-b37c-bb02bc5bf7c6).

Lithium

Mood stabilizer

Brands: Lithobid, Eskalith

View Lithium safety profile

Valsartan

Angiotensin receptor blocker (ARB)

Brands: Diovan

View Valsartan safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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