Does Dapagliflozin Interact With Valsartan?
No dosing adjustments required for the following: Oral Antidiabetic Agents Metformin (1000 mg) 20 mg ↔ ↔ Pioglitazone (45 mg) 50 mg ↔ ↔ Sitagliptin (100 mg) 20 mg ↔ ↔ Glimepiride (4 mg) 20 mg ↔ ↔ Voglibose (0.2 mg three times daily) 10 mg ↔ ↔ Other Medications Hydrochlorothiazide (25 mg) 50 mg ↔ ↔ Bumetanide (1 mg) 10 mg once daily for 7 days ↔ ↔ Valsartan (320 mg) 20 mg ↓12% [↓3%, ↓20%] ↔ Simvastatin (40 mg) 20 mg ↔ ↔ Anti-infective Agent Rifampin (600 mg once daily for 6 days) 10 mg ↓7% [↓2…
Severity: Minor
Severity basis: drug interactions section. Combining Dapagliflozin (SGLT2 inhibitor) and Valsartan (Angiotensin receptor blocker (ARB)) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
No dosing adjustments required for the following: Oral Antidiabetic Agents Metformin (1000 mg) 20 mg ↔ ↔ Pioglitazone (45 mg) 50 mg ↔ ↔ Sitagliptin (100 mg) 20 mg ↔ ↔ Glimepiride (4 mg) 20 mg ↔ ↔ Voglibose (0.2 mg three times daily) 10 mg ↔ ↔ Other Medications Hydrochlorothiazide (25 mg) 50 mg ↔ ↔ Bumetanide (1 mg) 10 mg once daily for 7 days ↔ ↔ Valsartan (320 mg) 20 mg ↓12% [↓3%, ↓20%] ↔ Simvastatin (40 mg) 20 mg ↔ ↔ Anti-infective Agent Rifampin (600 mg once daily for 6 days) 10 mg ↓7% [↓2…
Source: FDA structured product labeling (set_id 01f90c94-71cb-4a1f-81ff-8004b850529b).
Check these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Dapagliflozin Interactions
- Dapagliflozin + Lithium(moderate)
- Dapagliflozin + Digoxin(minor)
- Dapagliflozin + Glimepiride(minor)
- Dapagliflozin + Hydrochlorothiazide(minor)
- Dapagliflozin + Metformin(minor)
- Dapagliflozin + Pioglitazone(minor)
- Dapagliflozin + Rifampin(minor)
- Dapagliflozin + Simvastatin(minor)
- Dapagliflozin + Sitagliptin(minor)
- Dapagliflozin + Warfarin(minor)