Does Morphine Interact With Ticagrelor?

Consider the use of a parenteral anti-platelet agent in acute coronary syndrome patients requiring co-administration of morphine or other opioid agonists.

Severity: Moderate

Severity basis: drug interactions section (keywords: consider). Combining Morphine (Opioid analgesic) and Ticagrelor (P2Y12 antiplatelet) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Consider the use of a parenteral anti-platelet agent in acute coronary syndrome patients requiring co-administration of morphine or other opioid agonists.

Source: FDA structured product labeling (set_id 1225fd45-9b56-1671-ee77-cd0c9f2174a5).

Morphine

Opioid analgesic

Brands: MS Contin, Kadian

View Morphine safety profile

Ticagrelor

P2Y12 antiplatelet

Brands: Brilinta

View Ticagrelor safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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