Does Morphine Interact With Oxycodone?

(7) Monoamine Oxidase Inhibitors (MAOIs) : Can potentiate the effects of morphine.

Severity: Minor

Severity basis: drug interactions section. Combining Morphine (Opioid analgesic) and Oxycodone (Opioid analgesic) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

(7) Monoamine Oxidase Inhibitors (MAOIs) : Can potentiate the effects of morphine.

Source: FDA structured product labeling (set_id 01db4606-d49c-4b10-a78a-1cf41880a9fb).

Morphine

Opioid analgesic

Brands: MS Contin, Kadian

View Morphine safety profile

Oxycodone

Opioid analgesic

Brands: OxyContin, Roxicodone, Percocet

View Oxycodone safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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