Does Itraconazole Interact With Ticagrelor?

This combination is contraindicated on the FDA label. Do not take these together unless your prescriber explicitly directs it.

Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Itraconazole is a azole antifungal (strong cyp3a4 inhibitor) and Ticagrelor is a p2y12 antiplatelet; together they are documented as a contraindicated interaction. How much this matters depends on your dose, your other medications, and your overall health.

If you have been prescribed both Itraconazole and Ticagrelor, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

Some examples of drugs for which plasma concentrations increase are: methadone, disopyramide, dofetilide, dronedarone, quinidine, isavuconazole, ergot alkaloids (such as dihydroergotamine, ergometrine (ergonovine), ergotamine, methylergometrine (methylergonovine), irinotecan, lurasidone, oral midazolam, pimozide, triazolam, felodipine, nisoldipine, ivabradine, ranolazine, eplerenone, cisapride,naloxegol, lomitapide, lovastatin, simvastatin, avanafil, ticagrelor, finerenone, voclosporin.

Source: FDA structured product labeling (set_id 23126370-8d6a-4027-bd8f-860e2776ba3a).