Does Cyclobenzaprine Interact With Morphine?
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that effect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).
Severity: Minor
Severity basis: drug interactions section. Combining Cyclobenzaprine (Skeletal muscle relaxant) and Morphine (Opioid analgesic) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that effect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).
Source: FDA structured product labeling (set_id 07593aa4-f2c4-4d6e-b186-ab2a4ecaa38a).
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Cyclobenzaprine Interactions
Other Morphine Interactions
- Morphine + Buprenorphine Naloxone(major)
- Morphine + Clopidogrel(moderate)
- Morphine + Codeine(moderate)
- Morphine + Gabapentin(moderate)
- Morphine + Ticagrelor(moderate)
- Morphine + Alprazolam(minor)
- Morphine + Mirtazapine(minor)
- Morphine + Oxycodone(minor)
- Morphine + Rifampin(minor)
- Morphine + Tramadol(minor)
- Morphine + Trazodone(minor)
- Morphine + Verapamil(minor)