Does Adalimumab Interact With Methotrexate?
Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids.
Severity: Moderate
Severity basis: boxed warning (keywords: boxed warning). Combining Adalimumab (TNF inhibitor biologic) and Methotrexate (Antimetabolite DMARD) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
From the FDA Label
Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids.
Source: FDA structured product labeling (set_id 08dbaffe-9d05-43cf-b24b-b44ade8685fc).
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Adalimumab Interactions
Other Methotrexate Interactions
- Methotrexate + Aspirin(major)
- Methotrexate + Folic Acid(major)
- Methotrexate + Phenytoin(major)
- Methotrexate + Celecoxib(moderate)
- Methotrexate + Furosemide(moderate)
- Methotrexate + Hydroxychloroquine(moderate)
- Methotrexate + Indomethacin(moderate)
- Methotrexate + Meloxicam(moderate)
- Methotrexate + Naproxen(moderate)
- Methotrexate + Cyclosporine(minor)
- Methotrexate + Lansoprazole(minor)
- Methotrexate + Ondansetron(minor)
- Methotrexate + Pantoprazole(minor)