Does Indomethacin Interact With Methotrexate?

Methotrexate Clinical Impact: Concomitant use of NSAIDs and methotrexate may increase the risk for methotrexate toxicity (e.g., neutropenia, thrombocytopenia, renal dysfunction).

Severity: Moderate

Severity basis: drug interactions section (keywords: may increase). Combining Indomethacin (Nonsteroidal anti-inflammatory drug (NSAID)) and Methotrexate (Antimetabolite DMARD) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Methotrexate Clinical Impact: Concomitant use of NSAIDs and methotrexate may increase the risk for methotrexate toxicity (e.g., neutropenia, thrombocytopenia, renal dysfunction).

Source: FDA structured product labeling (set_id 009097a5-2c1e-4f5d-8054-896cf896cb3d).

Indomethacin

Nonsteroidal anti-inflammatory drug (NSAID)

Brands: Indocin

View Indomethacin safety profile

Methotrexate

Antimetabolite DMARD

Brands: Trexall, Otrexup, Rasuvo

View Methotrexate safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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