Does Methotrexate Interact With Naproxen?

Methotrexate Clinical Impact: Concomitant use of NSAIDs and methotrexate may increase the risk for methotrexate toxicity (e.g., neutropenia, thrombocytopenia, renal dysfunction).

Severity: Moderate

Severity basis: drug interactions section (keywords: may increase). Combining Methotrexate (Antimetabolite DMARD) and Naproxen (Nonsteroidal anti-inflammatory drug (NSAID)) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Methotrexate Clinical Impact: Concomitant use of NSAIDs and methotrexate may increase the risk for methotrexate toxicity (e.g., neutropenia, thrombocytopenia, renal dysfunction).

Source: FDA structured product labeling (set_id 000155a8-709c-44e5-a75f-cd890f3a7caf).

Methotrexate

Antimetabolite DMARD

Brands: Trexall, Otrexup, Rasuvo

View Methotrexate safety profile

Naproxen

Nonsteroidal anti-inflammatory drug (NSAID)

Brands: Aleve, Naprosyn

View Naproxen safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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