Does Cyclosporine Interact With Methotrexate?

The risk of cutaneous malignancies is further increased when cyclosporine is administered to patients with psoriasis who received prior methotrexate.

Severity: Minor

Severity basis: warnings section. Combining Cyclosporine (Calcineurin inhibitor immunosuppressant) and Methotrexate (Antimetabolite DMARD) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

The risk of cutaneous malignancies is further increased when cyclosporine is administered to patients with psoriasis who received prior methotrexate.

Source: FDA structured product labeling (set_id 04a95db9-a124-4b97-bd71-1c37a6b3b0c8).

Cyclosporine

Calcineurin inhibitor immunosuppressant

Brands: Neoral, Sandimmune, Gengraf

View Cyclosporine safety profile

Methotrexate

Antimetabolite DMARD

Brands: Trexall, Otrexup, Rasuvo

View Methotrexate safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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