Does Colchicine Interact With Itraconazole?

This combination is contraindicated on the FDA label. Do not take these together unless your prescriber explicitly directs it.

Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Colchicine is a anti-gout agent and Itraconazole is a azole antifungal (strong cyp3a4 inhibitor); together they are documented as a contraindicated interaction. How much this matters depends on your dose, your other medications, and your overall health.

If you have been prescribed both Colchicine and Itraconazole, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

In addition, coadministration with colchicine, fesoterodine and solifenacin is contraindicated in subjects with varying degrees of renal or hepatic impairment, and coadministration with eliglustat is contraindicated in subjects that are poor or intermediate metabolizers of CYP2D6 and in subjects taking strong or moderate CYP2D6 inhibitors.

Source: FDA structured product labeling (set_id 23126370-8d6a-4027-bd8f-860e2776ba3a).