Does Colchicine Interact With Gemfibrozil?

Concomitant use of atorvastatin, simvastatin, pravastatin, fluvastatin, lovastatin, gemfibrozil, fenofibrate, fenofibric acid or benzafibrate (themselves associated with myotoxicity) or cyclosporine with colchicine tablets may potentiate the development of myopathy [see Error!

Severity: Moderate

Severity basis: warnings section (keywords: may potentiate). Combining Colchicine (Anti-gout agent) and Gemfibrozil (Fibrate) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Concomitant use of atorvastatin, simvastatin, pravastatin, fluvastatin, lovastatin, gemfibrozil, fenofibrate, fenofibric acid or benzafibrate (themselves associated with myotoxicity) or cyclosporine with colchicine tablets may potentiate the development of myopathy [see Error!

Source: FDA structured product labeling (set_id 0f69b9c6-8c00-45e2-b950-34dc5ae62352).

Colchicine

Anti-gout agent

Brands: Colcrys, Mitigare

View Colchicine safety profile

Gemfibrozil

Fibrate

Brands: Lopid

View Gemfibrozil safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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