Does Clarithromycin Interact With Colchicine?

4.4 Colchicine Concomitant administration of clarithromycin tablets and colchicine is contraindicated in patients with renal or hepatic impairment.

Severity: Contraindicated

Severity basis: contraindications section (keywords: contraindicated). Combining Clarithromycin (Macrolide antibiotic) and Colchicine (Anti-gout agent) is classified as a contraindicated interaction.

What to Do

This combination is contraindicated on the FDA label. Do not take these together unless your prescriber explicitly directs it.

From the FDA Label

4.4 Colchicine Concomitant administration of clarithromycin tablets and colchicine is contraindicated in patients with renal or hepatic impairment.

Source: FDA structured product labeling (set_id 0be243c6-de02-45dd-8210-cab1bbc8dfa7).

Clarithromycin

Macrolide antibiotic

Brands: Biaxin

View Clarithromycin safety profile

Colchicine

Anti-gout agent

Brands: Colcrys, Mitigare

View Colchicine safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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