Does Atorvastatin Interact With Verapamil?

Lower starting and maintenance doses of other CYP3A4 substrates (e.g., atorvastatin) may be required as verapamil may increase the plasma concentration of these drugs.

Severity: Moderate

Severity basis: drug interactions section (keywords: may increase). Combining Atorvastatin (HMG-CoA reductase inhibitor (statin)) and Verapamil (Calcium channel blocker) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Lower starting and maintenance doses of other CYP3A4 substrates (e.g., atorvastatin) may be required as verapamil may increase the plasma concentration of these drugs.

Source: FDA structured product labeling (set_id 006cf920-04ae-0b53-cb91-85481972abc2).

Atorvastatin

HMG-CoA reductase inhibitor (statin)

Brands: Lipitor

View Atorvastatin safety profile

Verapamil

Calcium channel blocker

Brands: Calan, Verelan

View Verapamil safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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