Does Atorvastatin Interact With Estradiol?
Oral Contraceptives: May increase plasma levels of norethindrone and ethinyl estradiol; consider this effect when selecting an oral contraceptive (7.3 ).
Severity: Moderate
Severity basis: drug interactions section (keywords: may increase, consider). Combining Atorvastatin (HMG-CoA reductase inhibitor (statin)) and Estradiol (Estrogen) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Atorvastatin is a hmg-coa reductase inhibitor (statin) and Estradiol is a estrogen; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Atorvastatin and Estradiol, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
Oral Contraceptives: May increase plasma levels of norethindrone and ethinyl estradiol; consider this effect when selecting an oral contraceptive (7.3 ).
Source: FDA structured product labeling (set_id 00afce9b-48c9-487a-a738-e359c005c707).
Check these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Atorvastatin and Estradiol together?
Atorvastatin and Estradiol have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How serious is the Atorvastatin and Estradiol interaction?
It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: may increase, consider). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.
What should I do if I'm taking both Atorvastatin and Estradiol?
If you have been prescribed both Atorvastatin and Estradiol, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Atorvastatin Interactions
- Atorvastatin + Clarithromycin(major)
- Atorvastatin + Cyclosporine(major)
- Atorvastatin + Gemfibrozil(major)
- Atorvastatin + Colchicine(moderate)
- Atorvastatin + Digoxin(moderate)
- Atorvastatin + Itraconazole(moderate)
- Atorvastatin + Phenytoin(moderate)
- Atorvastatin + Rifampin(moderate)
- Atorvastatin + Verapamil(moderate)
- Atorvastatin + Amiodarone(minor)
- Atorvastatin + Fluconazole(minor)
- Atorvastatin + Ketoconazole(minor)
- Atorvastatin + Warfarin(minor)