Does Atorvastatin Interact With Cyclosporine?

Concomitant use of cyclosporine, gemfibrozil, tipranavir plus ritonavir, or glecaprevir plus pibrentasvir with atorvastatin is not recommended.

Severity: Major

Severity basis: warnings section (keywords: not recommended). Combining Atorvastatin (HMG-CoA reductase inhibitor (statin)) and Cyclosporine (Calcineurin inhibitor immunosuppressant) is classified as a major interaction.

What to Do

The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.

From the FDA Label

Concomitant use of cyclosporine, gemfibrozil, tipranavir plus ritonavir, or glecaprevir plus pibrentasvir with atorvastatin is not recommended.

Source: FDA structured product labeling (set_id 00afce9b-48c9-487a-a738-e359c005c707).

Atorvastatin

HMG-CoA reductase inhibitor (statin)

Brands: Lipitor

View Atorvastatin safety profile

Cyclosporine

Calcineurin inhibitor immunosuppressant

Brands: Neoral, Sandimmune, Gengraf

View Cyclosporine safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

Questions About Your Medications?

A licensed OmniRx provider can review your full medication list and help you understand what's safe for you — no office visit required.